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Knives' gun (left) and Vash's gun (right), as seen in the series' intro.

The .45 Long Colt (EF Auto Ejecting, Double Action) is Vash and Knives' weapon of choice. The modern .45 Long Colt cartridge has ballistic properties equal to, or even surpassing, those of a .44 magnum cartridge. These guns are not based on normal revolvers, but are a mash-up of features from various real-world revolvers. Probable examples include a break action frame reminiscent of an MP412 REX, and a barrel with a low bore axis, firing from the bottom of the cylinder, similar to some Mateba revolvers.

The two depicted in the series are unique in design, both built by Knives, and can be used in two modes. First, as an ordinary revolver, and second, in a configuration known as The Angel Arm. Each gun is designed with a miniature Plant contained in a break-away housing along the top of the barrel. Activation causes the gun to fuse with the user's arm, transforming both gun and arm into a high-yield energy weapon capable of mass destruction. Only Vash and Knives are able to activate the Angel Arm.

During his 17 years inside the SEED ship, Knives salvaged the needed parts and Plant material to fashion this set. When questioned by Vash, Knives referred to them as "our Brothers." After Knives had shown Vash the destructive power of the two guns, Vash shot Knives in the leg and escaped, taking both Brothers with him. Knives eventually retrieved his gun from Vash during the July incident, severing Vash's left arm with a shot through his shoulder in the process.

Vash's gun is silver, while Knives' gun is black.

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