Trigun is a child's imagination when playing with toy guns...
Vash would be a 9 year old boy which would explain his kindness towards others
Rem would've been his big sister who died in a car accident
Wolfwood Is Vash's father who lost his wife in the same car accident Rem died in...
Meryl would be a friend from the school Vash goes to and would be Vash's crush
Milly is also a friend of Vash who also has a crush on Meryl...
Knives and the Gung ho guns are the school bullies...
And the finale of the anime would be a fist fight between Vash and Knives where Vash wins