AGL Arms .45 Long Colt

The .45 Long Colt (EF Auto Ejecting, Double Action) is Vash's and Knives' weapon of choice. The .45 Long Colt cartridge was a low impact cartridge developed at the turn of the 20th century due to its use of black powder, which would makes the range and penetration depicted in the anime conflict with real live performace of the cartrdige. On the other hand modern day loadings with modern smokeless powders can produce ballistic properties equal or even surpassing that of a 44 magnum. These guns aren't based off of normal revolvers, but are most likely a mash-up of various features from real world revolvers. Such as the break top reloading from a Smith and Wesson Schofield revolver. The bottom of the cylinder firing of a Mateba revolver (Chiappa's Rhino wasn't around yet). Also possibly the barrel of a Dan Wesson full under lug barrel (though inverted).

The two depicted in the series are unique in design as the both were built by Knives to be used in two separate stages. The first, described above in further detail, is a simple .45 colt Break Action Revolver. The second stage for each of these weapons is known as The Angel Arm. Each gun is designed with a miniature Plant contained in a break-away portion of the normally solid portions of each pistol. During his 17 years inside the SEED ship, Knives salvaged the needed parts and plant material to fashion this set. When ask what they were by Vash, Knives replied that they were "our Brothers." After Knives had shown Vash the destructive power of the two guns, Vash shot Knives in the leg and ran away taking both Brothers with him. Knives eventually retrieved his from Vash during the July incident, severing Vash's left arm with a shot through his shoulder in the process. Vash's gun is silver, while Knives's gun is black.

Trivia

 * The .45 Long Colt weighs in at around 150 lbs.